No
Here are my (personal) Cap MU numbers after fighting everyone multiple times and getting notes.
Favorable (6-4): Thanos, Nova, Black Panther, Haggar, Spencer, Venom
Unfavorable (4-6): Spider-Man, Frank (Lv.4+5), Sigma, Gamora
Even (5-5): Everyone else
I see Cap as very balanced overall, since I don’t think he has any highly favorable MUs, yet also no truly difficult ones. Feel free to discuss.