Ultimate spiderman has and always will be my favorite comic.
Outside of marvel/DC, Scott Pilgrim. I love me some scott Pilgrim
The Kabuki series by david mack. Its so deep, poetic, artistic, and still nothing else like it around.
The Runaways. A very welcomed change of pace in the marvel universe.
And anything alan moore. His stuff is just awesome.
The Walking Dead i just started reading this and its so addicting. Also, Preacher is really good.